Multi-omics analysis of the response to different immune checkpoint inhibitors at single cell resolution
Luigi Adamo, MD, PhD
Advanced Heart Failure and Cardiac Transplant Specialist
Director, Cardiac Immunology
Assistant Professor of Medicine
The Johns Hopkins University School of Medicine
Immunotherapy has revolutionized the treatment of oncologic patients. However, the target and extent of the immunomodulatory effect of different immune checkpoint inhibitors (ICIs) have not been fully elucidated. Taking advantage of a murine model of spontaneous thyroid cancer and single cell multi-omic analysis, we investigated the effect of three different ICIs on tumor progression and CD45+ organ infiltrating cells. We uncovered a broad, specific, tunable effect of ICIs. Our findings provide unexpected insights into the immunobiology of ICIs and highlight potential strategies for the optimization of immunotherapies.
Recording during the Illumina MORE Symposium.