Chromatin immunoprecipitation sequencing (ChIP-Seq) is used to determine how proteins interact with DNA to regulate gene expression. Partek provides easy-to-use tools that guide you through the entire analysis process from start to finish.
Visualizing aligned reads in ChIP sample and control sample, with detected peak region track.
TSS plot displays the read coverage around the transcription start sites within the detected peaks in ChIP sample.
Logo view of motif detected in the binding sites.
Alignment
Peak Detection
Peak Annotation
Motif Detection
Visualization
Fast and Easy ChIP-Seq Analysis
ChIP-Seq is a powerful method to detect genome-wide DNA binding sites for transcription factors and other proteins. Many tools are available on the market to detect peaks and discover motifs from peak sequences, but most are are command-line based. Partek provides a point-and-click interface making it fast and easy to build a start-to-finish ChIP-seq pipeline. Pipelines can also be easily built for other genomic locus analysis experiments such as ATAC-Seq, MNase-Seq, DNase-Seq, and more.
Integrate ChIP-Seq Data with Other Assays
Transcription factors (TF) control regulation of expression. Partek software allows you to easily integrate ChIP-Seq and RNA-Seq studies into a single study. Once peaks and TF binding sites are identified in ChIP-Seq data, peaks can be annotated to the genome to find the nearest transcription start site. A list of target genes generated from ChIP-Seq data can be compared with a list of differentially expressed genes generated from RNA-Seq data using a Venn diagram. The Partek chromosome view allows you to visualize the peaks and differentially expressed genes together.
